Abstract
General psychopathology and cognition are likely to have a bidirectional influence on each other. Yet, the relationship between brain structure, psychopathology, and cognition remains unclear. This brief report investigates the association between structural properties of the cerebral cortex [surface area, cortical thickness, intracortical myelination indexed by the T1w/T2w ratio, and neurite density assessed by restriction spectrum imaging (RSI)] with general psychopathology and cognition in a sample of children from the Adolescent Brain Cognitive Development (ABCD) study. Higher levels of psychopathology and lower levels of cognitive ability were associated with a smaller cortical surface area. Inter-regionally—across the cerebral cortex—the strength of association between an area and psychopathology is strongly correlated with the strength of association between an area and cognition. Taken together, structural deviations particularly observed in the cortical surface area influence both psychopathology and cognition.
Highlights
There is overwhelming evidence demonstrating the shared heritability of psychiatric disorders (Anttila et al, 2018)
We investigate the association between several properties of the cerebral cortex, namely the surface area, cortical thickness, the T1w/T2w ratio (Glasser and Van Essen, 2011), and neurite density [as indexed by restriction spectrum imaging (RSI)] (White et al, 2013), with general psychopathology and cognitive ability in a large sample of children from the Adolescent Brain Cognitive Development Study (ABCD) (Casey et al, 2018)
We reveal subtle yet robust associations between cortical structure and general psychopathology and cognitive ability (Figure 1 and Supplementary Figure 1)
Summary
There is overwhelming evidence demonstrating the shared heritability of psychiatric disorders (Anttila et al, 2018). The “p” factor, or general psychopathology factor, is one such approach capturing latent structures of psychopathology across many disorders (Lahey et al, 2012; Caspi et al, 2014). Impairments in cognitive functioning are observed across many psychiatric disorders (Gale et al, 2010; Urfer-Parnas et al, 2010). Conceptual frameworks have suggested a bidirectional relationship between cognitive function and psychopathology (Batty et al, 2005; Calvete et al, 2013; Schweizer and Hankin, 2018). With the advent of large-scale magnetic resonance imaging (MRI) studies, group differences in the structural properties of the cerebral cortex (predominantly cortical thickness) have been reported in common psychiatric disorders
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
