General information

Abstract

Circadian variation in the onset of acute aortic dissection (AAD) has been less investigated than other cardiovascular diseases. We performed a meta-analysis to assess the presence of an circadian rhythmic variability of AAD onset. Eligible studies were observational studies enrolling patients with AAD and reporting a circadian variation in AAD. Study-specific estimates, that is, 2-hour incidence of AAD, were combined using the random-effects model. Chronobiological analysis (analysis of circadian rhythmicity) was performed by applying a partial Fourier series to the pooled 2-hour incidence using the weighted least-squares method. We identified 7 eligible studies enrolling a total of 1,827 patients with AAD. Pooled 2-hour period incidence of AAD was 3.4% in 0:00 to 2:00, 4.8% in 2:00 to 4:00, 5.4% in 4:00 to 6:00, 9.6% in 6:00 to 8:00, 13.8% in 8:00 to 10:00, 11.1% in 10:00 to 12:00, 8.1% in 12:00 to 14:00, 8.9% in 14:00 to 16:00, 8.8% in 16:00 to 18:00, 7.0% in 18:00 to 20:00, 8.1% in 20:00 to 22:00), and 5.5% in 22:00 to 24:00. Chronobiological analysis (nonlinear Fourier rhythm analysis) identified a significant (p = 0.0082) circadian pattern in the occurrence of AAD with a peak in 8:00 to 10:00 and a nadir in 0:00 to 2:00. Pooled analysis demonstrated significantly more incidence in 8:00 to 10:00 than in 0:00 to 2:00 (risk ratio 3.59, 95% confidence interval 2.19 to 5.90, p<0.00001). The incidence of AAD was 8.8%, 15.5%, 25.0%, 17.7%, 16.1%, and 13.8% in 0:00 to 4:00, 4:00 to 8:00, 8:00 to 12:00, 12:00 to 16:00, 16:00 to 20:00, and 20:00 to 24:00, respectively. A significant circadian pattern was found in the occurrence of AAD with a peak in 8:00 to 10:00 and a nadir in 0:00 to 2:00.