Abstract
Haldane's laws, which apply to situations in which CO and O 2 compete for the four heme sites of hemoglobin, are discussed in general statistical mechanical terms. Necessary and sufficient conditions for the validity of Haldane's laws are presented and discussed for general situations in which two ligands compete for interacting active sites on a molecule. Our considerations therefore apply to a competing substrate-inhibitor-allosteric enzyme system for example, as well as to hemoglobin. A generalization of the Monod-Wyman-Changeux model for competing ligands is briefly discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
