Abstract
The quantal release of acetylcholine (ACh) by an impulse at preganglionic terminals generates an excitatory postsynaptic potential (EPSP) at the subsynaptic membrane of a postganglionic neuron. This EPSP exhibits a rapid rise and a relatively slow decay with a time constant somewhat longer than the membrane time constant. In view of its temporal characteristics, it has been termed the fast EPSP (cf. Nishi, 1974; Kuba and Koketsu, 1978] to distinguish it from other EPSPs such as the slow EPSP and the late slow EPSP. The fast EPSP is unequivocally induced by the nicotinic action of ACh, since it is depressed by D-tubocurarine or β-erythroidine (Eccles, 1963; Blackman et al., 1963) and less by atropine and is augmented by anticholinesterases.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
