Abstract
SummaryCardiac output, vascular pressures, coronary sinus flow, cardiac O2 usage and efficiency, together with blood glucose and non‐esterified fatty acid (NEFA) values, were measured before and after the infusion of Tween 20 (polyoxyethylene sorbitan monolaurate) in intact anaesthetised dogs. This substance, which releases histamine, gave the following responses: an initial increase in cardiac output, coronary sinus flow and heart rate, with maintenance of systemic pressure; 3‐4 minutes later, cardiac output, vascular pressures and coronary flow decreased greatly, with a continuance of the tachycardia. Cardiac work decreased, as did cardiac efficiency; blood glucose levels did not change, but NEFA values and cardiac NEFA extraction increased.The biphasic response described is entirely compatible with histamine release, the later response being almost indistinguishable from that found in endotoxin or haemorrhagic shock.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Australian journal of experimental biology and medical science
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
