Abstract
ABSTRACT Mononucleated striated muscle of an anthomedusa can be isolated and cultivated in artificial sea water. When treated with bacterial collagenase the isolated muscle can transdifferentiate autonomously into several cell types and regenerate the entire sexual and feeding organ of the medusa, the manubrium. Whereas transdifferentiation from striated to smooth muscle is direct, formation of a glandular cell type needs one cell cycle. Aphidicolin experiments show that this one cell cycle has to be initiated at the right time otherwise transdifferentiation of striated muscle to the glandular cell type does not occur.
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