Abstract
Although both genetics and environmental factors play important roles in the etiology of type 2 diabetes (T2D), the extent to which genetics influence the environment (or vice versa) is still an open question. In this chapter, we first motivate the study of gene-environment (G × E) interaction with T2D, present statistical models of interaction, and then share illustrating examples of G × E interaction in the literature: PPGARG with T2D, COBLL1/GRB14 with fasting insulin levels and FTO with T2D, obesity, and physical activity.
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