Gene-environment Interaction Between Tlr4+8595c/t Polymorphism And Bronchiolitis May Influence The Development Of Asthma In Preschool Children

Abstract

RationaleBrochiolitis has been well known risk factor to the development of asthma. Toll like receptor (TLR) 4 was linked to innate immunity and the development of allergic diseases. TLR4 polymorphism was associated with susceptibility of RSV known as major cause of bronchiolitis. The aim of this study was to investigate the gene-environment interaction between TLR4 +8595C/T polymorphism and bronchiolitis in the development of asthma.MethodsA modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 933 pre-school children from nine urban areas of Seoul in Korea. TLR4 +8595C/T(rs1927917) polymorphism was genotyped by TaqMan assay.ResultsThe lifetime prevalence of asthma diagnosis was 8.7% and the recent 12-month prevalence of asthma treatment was 4.4%. Maternal history of asthma (aOR, 4.02; 95% CI, 1.40-11.52), parental history of AR (aOR, 3.48; 95% CI, 1.95-6.19), the use of antibiotics during infancy (aOR, 1.86; 95% CI, 1.07-3.19) and past history of bronchiolitis (aOR, 4.83; 95% CI, 1.79-13.01) were independent risk factors for asthma diagnosis and treatment. In children with CT+TT genotype of TLR4 +8595C/T polymorphism, past history of bronchiolitis increased the risks of asthma diagnosis (aOR, 4.83; 95% CI, 1.79-13.01).ConclusionFamily history of asthma or AR, past history of bronchiolitis and the use of antibiotics during infancy could be the independent risk factors for the development of asthma. The gene-environment interaction between TLR4 +8595C/T polymorphism and bronchiolitis may influence the development of asthma in preschool children. RationaleBrochiolitis has been well known risk factor to the development of asthma. Toll like receptor (TLR) 4 was linked to innate immunity and the development of allergic diseases. TLR4 polymorphism was associated with susceptibility of RSV known as major cause of bronchiolitis. The aim of this study was to investigate the gene-environment interaction between TLR4 +8595C/T polymorphism and bronchiolitis in the development of asthma. Brochiolitis has been well known risk factor to the development of asthma. Toll like receptor (TLR) 4 was linked to innate immunity and the development of allergic diseases. TLR4 polymorphism was associated with susceptibility of RSV known as major cause of bronchiolitis. The aim of this study was to investigate the gene-environment interaction between TLR4 +8595C/T polymorphism and bronchiolitis in the development of asthma. MethodsA modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 933 pre-school children from nine urban areas of Seoul in Korea. TLR4 +8595C/T(rs1927917) polymorphism was genotyped by TaqMan assay. A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 933 pre-school children from nine urban areas of Seoul in Korea. TLR4 +8595C/T(rs1927917) polymorphism was genotyped by TaqMan assay. ResultsThe lifetime prevalence of asthma diagnosis was 8.7% and the recent 12-month prevalence of asthma treatment was 4.4%. Maternal history of asthma (aOR, 4.02; 95% CI, 1.40-11.52), parental history of AR (aOR, 3.48; 95% CI, 1.95-6.19), the use of antibiotics during infancy (aOR, 1.86; 95% CI, 1.07-3.19) and past history of bronchiolitis (aOR, 4.83; 95% CI, 1.79-13.01) were independent risk factors for asthma diagnosis and treatment. In children with CT+TT genotype of TLR4 +8595C/T polymorphism, past history of bronchiolitis increased the risks of asthma diagnosis (aOR, 4.83; 95% CI, 1.79-13.01). The lifetime prevalence of asthma diagnosis was 8.7% and the recent 12-month prevalence of asthma treatment was 4.4%. Maternal history of asthma (aOR, 4.02; 95% CI, 1.40-11.52), parental history of AR (aOR, 3.48; 95% CI, 1.95-6.19), the use of antibiotics during infancy (aOR, 1.86; 95% CI, 1.07-3.19) and past history of bronchiolitis (aOR, 4.83; 95% CI, 1.79-13.01) were independent risk factors for asthma diagnosis and treatment. In children with CT+TT genotype of TLR4 +8595C/T polymorphism, past history of bronchiolitis increased the risks of asthma diagnosis (aOR, 4.83; 95% CI, 1.79-13.01). ConclusionFamily history of asthma or AR, past history of bronchiolitis and the use of antibiotics during infancy could be the independent risk factors for the development of asthma. The gene-environment interaction between TLR4 +8595C/T polymorphism and bronchiolitis may influence the development of asthma in preschool children. Family history of asthma or AR, past history of bronchiolitis and the use of antibiotics during infancy could be the independent risk factors for the development of asthma. The gene-environment interaction between TLR4 +8595C/T polymorphism and bronchiolitis may influence the development of asthma in preschool children.