Abstract
The presence of a complex population of gene transcripts in mature human sperm is well established, and numerous mRNAs and non-coding mRNAs have been identified in sperm of men and other mammalian species using microarray and RT-PCR. The traditional concept that RNAs in mature sperm are only remnants from spermatogenesis and have no biological functions is in doubt. The findings that reverse transcriptases in sperm are active and that sperm can independently activate translation of stored mRNAs suggest that sperm RNAs may have significant effects on male fertility. The differences in expression profiles among RNAs in mature sperm from fertile and infertile men, and the regulation of sperm RNAs in embryonic development make them appealing markers for therapeutic and diagnostic tools in male infertility. In this review, methods for the detection and description of the diversity of gene transcript in sperm are discussed along with their putative roles in functional aspects of sperm and in embryogenesis.
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