Abstract
Gene Therapy Research at the Frontiers of Viral Immunology
Highlights
Viral vectors such as adenovirus and adenovirus-associated virus (AAV) are superior tools for gene therapy due to their high efficiency of transduction into a variety of cells in vivo
The first review article of this special topic provides a comprehensive overview of the innate immune responses to AAV
The innate immune response to singlestranded AAVs has been considered weak and transient when compared to the potent and prolonged response elicited by Ad vectors, prompting many investigators to focus more on the adaptive immune response to AAV
Summary
Viral vectors such as adenovirus and adenovirus-associated virus (AAV) are superior tools for gene therapy due to their high efficiency of transduction into a variety of cells in vivo. Administration of viral vectors often provokes the initiation of innate and antigen-specific adaptive immune responses against the virus and/or the therapeutic transgene products.
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