Abstract
The obstruction of small airways by mucus plays a central pathophysiologic role in most cases of fatal asthma. T helper type-2 cytokines, such as interleukin (IL)-4, IL-9, and IL-13, rapidly cause dramatic metaplasia of the murine airway epithelium from a nonsecretory ciliated phenotype to mucus-secreting goblet cells in experimental allergic asthma. Accompanying this metaplasia, we have found that the exocytic regulatory protein Munc18–2 is strongly induced in the airway epithelium and that its promoter contains GATA factor, STAT-6, glucocorticoid receptor, and CREB binding sites.
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