Gene Therapy For Neurological Disorders: Parkinson’s Disease And Glioblastoma

Abstract

Gene therapy, though first proposed as a concept decades ago, has faced numerous setbacks in the form of serious adverse effects during early clinical trials. However, recent successes in the field as applied to neuromuscular disease, blindness, and cancer have stimulated renewed interest in the application of gene therapy for clinically intractable diseases. Neurological diseases, which have been proven to be some of the most lethal and hardest-to-treat disorders, lack and require additional treatments and attention. In this review, we focus on the methods of gene therapy, and how this type of treatment, delivered through a diverse repertoire of vector systems, is showing promising results in treating patients suffering from glioblastoma and Parkinson’s disease.