Abstract
Email: joonkyoo@chonnam.ac.kr Phone: +82-61-379-7760 Objective: KITENIN (KAI1 COOH-terminal interacting tetraspanin) has been found to act as a promoter of metastasis in murine models of colon cancer and squamous cell carcinoma(SCC). The suppression of tumor progression and metastasis of established colon cancer in mice was observed after intravenous delivery of small interfering RNA (siRNA) targeting KITENIN. The purpose of this study was to investigate the efficacy of gene therapy targeting KITENIN in human head and neck SCC.
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