Gene Relation Discovery by Mining Similar Subsequences in Time-Series Microarray Data

Abstract

Time-series microarray techniques are newly used to monitor large-scale gene expression profiles for studying biological systems. Previous studies have discovered novel regulatory relations among genes by analyzing time-series microarray data. In this study, we investigate the problem of mining similar subsequences in time-series microarray data so as to discover novel gene relations. A functional relationship among genes often presents itself by locally similar and potentially time-shifted patterns in their expression profiles. Although a number of studies have been done on time-series data analysis, they are insufficient in handling four important issues for time-series microarray data analysis, namely scaling, offset, shift, and noise. We proposed a novel method to address the four issues simultaneously, which consists of three phase, namely angular transformation, symbolic transformation and suffix-tree-based similar subsequences searching. Through experimental evaluation, it is shown that our method can effectively discover biological relations among genes by identifying the similar subsequences. Moreover, the execution efficiency of our method is much better than other approaches