Abstract
As obesity is a multifactorial characteristic, identifying genetic risk factors can help to prevent obesity prevalence. In 2007, FTO (fat mass and obesity associated) gene was identified according to genome-wide association study. Several studies revealed that FTO polymorphisms are responsible for the risk of obesity. The primary objective of our study was assessment of FTO rs9939609 and rs9926289 polymorphisms as risk factors of obesity in part of the Iranian population. In our case–control study, 62 patients with obesity and 75 controls were selected according to their BMI (obese: BMI ≥ 30 kg/m2 and control: BMI: 18.5-24.9 kg/m2). Blood samples were collected from individuals for biochemical parameters assessment and genotyping analysis. After genotyping by high resolution melting (HRM) technique, the odds ratio was used to examine the relationship between the risk factors and the disease; 95% of confidence interval was used for these calculations. The difference in the age, FBS, triglycerides, total cholesterol, and BMI between individuals with obesity and the control group was significant. The analysis of rs9939609 FTO gene showed significant association between the AA+TA genotype and TT according to the dominant model. No association was observed for genotypes of the FTO rs9926289 polymorphism. In addition, there was no significant correlation of biochemical parameters and dominant model genotypes of rs9939609 polymorphisms. Our study suggests that FTO rs9939609 polymorphisms appear to be associated with obesity in part of the Iranian population. AA+TA genotype of rs9939609 polymorphism is a risk factor of obesity. However, further examination should be carried out on large populations.
Highlights
Over the past 30 years, overweight and obesity have become one of the world’s leading health concerns
Obesity establishes a major public health and clinical challenge, as it is associated with an increased risk of metabolic abnormalities such as dyslipidemia, hypertension, type 2 diabetes (T2D), and cardiovascular diseases (CVD) [1]
In 2007, a genome-wide association study for T2D revealed a strong association between common single nucleotide polymorphisms (SNPs) in the fat mass and obesity–associated gene (FTO) region and the risk of T2D [3]
Summary
Over the past 30 years, overweight and obesity have become one of the world’s leading health concerns. Obesity establishes a major public health and clinical challenge, as it is associated with an increased risk of metabolic abnormalities such as dyslipidemia, hypertension, type 2 diabetes (T2D), and cardiovascular diseases (CVD) [1]. Similar to many complex diseases, obesity results from the interaction between genes and environmental factors [2]. In 2007, a genome-wide association study for T2D revealed a strong association between common single nucleotide polymorphisms (SNPs) in the fat mass and obesity–associated gene (FTO) region and the risk of T2D [3]. Research on FTO rs9939609 polymorphism revealed a significant correlation between risk of obesity and type 2 diabetes mellitus [5,6,7,8,9]. The rs9939609 and rs9926289 FTO polymorphisms are closely linked in the FTO gene, and some researchers verify their joint effects [7, 11]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
