Abstract
We examined the multigenetic index on the progression of laryngeal carcinoma in Chinese population. This study aims to assess the effects of single nucleotide polymorphisms (SNPs) on survival of Laryngeal Carcinoma (LC) patients. Eighteen SNPs were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 170 resected Chinese LC patients. Multivariate Cox proportional hazards model and Kaplan-Meier curve were used for the prognosis analysis. Overall, the median survival time (MST) was 38.00 months. The one, three and five year Kaplan-Meier survival rate was 0.847 ± 0.028, 0.572 ± 0.038 and 0.471 ± 0.041 respectively. The risks of death with the Hazard Ratio (HR) [95% confidence intervals] (CI) of 2.40 (1.15–4.50), 2.17 (1.45–3.25), 2.39 (1.58–3.62), 3.29 (2.10–5.18), respectively. There was significant associations between the SNPs and OS when the entire study population was examined. The rs1321311 TG genotype (vs.GG), rs2494938 AA genotype (vs. GG) and rs9363918 TG genotype (vs. GG) were associated with a worse prognosis for OS (adjusted HR = 1.64; 95%confidence interval = 1.07–2.51; P = 0.022, adjusted HR = 2.85; P =0.12; adjusted HR = 1.78; P = 0.009; respectively).The results suggest for the first time that these gene polymorphisms may serve as an independent prognostic marker for LC patients.
Highlights
Laryngeal carcinoma (LC) is one of the most frequently diagnosed malignant tumors in the Department of Otolaryngology - Head and Neck Surgery at the First Affiliated Hospital of Xi’an Jiaotong University [1]
We examined whether 18 Single-nucleotide polymorphism (SNP) located on chromosomes 5, 6, and 7 were associated with survival in a cohort of 170 resected laryngeal carcinoma (LC) patients
The T/G genotype at SNP rs1321311, the A/A genotype at SNP rs2494938, and the T/G genotype at SNP rs9363918 were associated with shorter overall survival (OS) in Laryngeal Carcinoma (LC) patients
Summary
Laryngeal carcinoma (LC) is one of the most frequently diagnosed malignant tumors in the Department of Otolaryngology - Head and Neck Surgery at the First Affiliated Hospital of Xi’an Jiaotong University [1]. LC can spread by directly invading adjacent structures, by metastasizing to regional cervical lymph nodes, or through the blood stream to more distant locations; among these, distant metastases in the lungs are the most common [2, 3]. Local recurrence after treatment is common, occurring in 10 to 50% of patients, and five-year survival rates in the United States are 60%. Adverse clinical prognostic factors in LC include advanced disease stage and poor performance status. Clinical factors often do not accurately predict LC outcomes, and a number of molecular markers accurately predict overall survival, none are currently used in the clinical setting [4]
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