Abstract
Objective: To investigate the distribution of the single nucleotide polymorphism (SNP) of LTC4S A-444C in children with Kawasaki disease in northern China and determine whether LTC4S A-444C SNP is associated with aspirin-induced urticaria (AIU).Methods: The clinical data of children with Kawasaki disease hospitalized in our center from April 2015 to November 2017 were collected, and fluorescence in situ hybridization was used to detect the LTC4S A-444C. According to the genotype, the subjects were divided into three groups: AA genotypes, AC genotypes, and CC genotypes. The incidence of AIU in the three groups was calculated and the relationship between LTC4S A-444C SNP and AIU was analyzed.Results: (1) A total of 574 children with Kawasaki disease were enrolled in the study. The allele frequencies for A, C were 980 (85.4%), 168 (14.6%). (2) Twenty-five cases of AIU in AA genotypes, with a positive rate of 6%, 11 cases of AIU in AC genotypes, with a positive rate of 7.5%, 2 cases of AIU in CC genotypes, with a positive rate of 18.2%. CC genotypes had higher incidence of AIU than that of AA and AC genotypes. However, there was no significant difference among the three groups (P > 0.05).Conclusion: The proportion of CC genotypes of LTC4S A-444C in children with Kawasaki disease in northern China is lower than that of AA genotypes and AC genotypes, and the incidence of AIU of CC genotypes is higher than that of AC genotypes and AA genotypes.
Highlights
Kawasaki disease is a febrile disease predominantly occurring in children under 5 years of age, and coronary artery complications are the most common cause of acquired heart disease in children
During the period of the study, total 651 children with Kawasaki disease hospitalized in our department, including 586 cases of complete Kawasaki disease and 65 cases of incomplete Kawasaki disease, in which 37 cases with a history of aspirin allergy themselves or their families, 13 cases who were not suitable for aspirin due to influenza or varicella, cases of intravenous immunoglobulin (IVIG) resistance, 6 cases of virus infection and cases who refused to participate in the study, 574 cases were included in the study
The present study provided the data of the distribution of LTC4S A-444C in children with Kawasaki disease in northern China
Summary
Kawasaki disease is a febrile disease predominantly occurring in children under 5 years of age, and coronary artery complications are the most common cause of acquired heart disease in children. The guidelines for the treatment of Kawasaki disease in the United States, Japan and China all indicate that high-dose aspirin should be taken in the acute stage and low-dose aspirin should be taken in the convalescent stage. Aspirin has become the routine and preferred approach in the treatment of children with Kawasaki disease [1,2,3]. Aspirin-induced urticaria (AIU) can occur in children with Kawasaki disease during aspirin administration. Drug hypersensitivity syndrome can be induced, which endangers the life of the patient and affects the clinical application. How to predict and prevent AIU early? Previous relevant literature reported the diagnosis of aspirin allergy mainly
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