Gene polymorphism associated with angiotensinogen (M235T), endothelial lipase (584C/T) and susceptibility to coronary artery disease: a meta-analysis.

Hongyan Zhao,Jidong Rong,Ranzun Zhao,Shan Hu

doi:10.1042/bsr20201414

Abstract

Objective: To explore the association between the variant M235T locus of angiotensinogen (AGT) gene, 584C/T locus of Endothelial lipase (EL) gene, and coronary artery disease (CAD) by meta-analysis.Methods: The case–control studies on the association between AGT/EL gene polymorphism and CAD were collected through searching PubMed, Excerpta Medica Database (EMBASE), Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases up to 1 March 2020. Stata 15.0 software was used for analysis.Results: A total of 29 articles met the inclusion criteria. After analyzing, it was found that the M235T polymorphism of AGT gene was associated with the occurrence of CAD. In the allele model (T vs. M), OR = 1.38 (P<v0.05). In other heredity, there was also statistical significance. Subgroup analysis indicated that except the heterozygous genetic model of the Chinese population, other genetic models of the Caucasian and Chinese population were also statistically significant. The 584C/T polymorphism of EL gene was associated with the occurrence of CAD, with OR = 0.83 (P<0.05) in the allele model (T vs. C) and OR = 0.80 (P<0.05) in the dominant gene model. Also, in the allele model of Caucasian subgroup, OR = 0.83 (P<0.05), while in Asian subgroup, there was no statistically significant genetic model.Conclusion: AGT M235T and EL 584C/T polymorphisms are associated with CAD susceptibility. The genotype TT, TC or allele T of AGT M235T and genotype CC or allele C of EL 584C/T might be the genetic risk factors for the development of CAD.

Highlights

Received: 27 April 2020Revised: 08 July 2020Accepted: 13 July 2020Accepted Manuscript online: Version of Record published: Coronary artery disease (CAD), the incidence of which is increasing year by year in both developed and developing countries, is the leading cause of deaths and seriously endangers human health [1,2]
With the increase in age, the incidence of CAD increases gradually [3]. Common risk factors, such as dyslipidemia, hypertension and diabetes, are affected by both environmental and genetic factors [4]. These traditional risk factors could not directly lead to CAD, and there might be other factors directly leading to atheromatous plaques formation that are related to genetic susceptibility
We systematically searched the relevant literatures of relationship between Angiotensinogen, Endothelial lipase Polymorphism and Coronary artery Disease on PubMed, Excerpta Medica Database (EMBASE), Web of Science, China National Knowledge Infrastructure (CNKI) and China Wanfang databases up to 1 March 2020

Summary

Introduction

Received: 27 April 2020Revised: 08 July 2020Accepted: 13 July 2020Accepted Manuscript online: Version of Record published: Coronary artery disease (CAD), the incidence of which is increasing year by year in both developed and developing countries, is the leading cause of deaths and seriously endangers human health [1,2]. With the increase in age, the incidence of CAD increases gradually [3]. Common risk factors, such as dyslipidemia, hypertension and diabetes, are affected by both environmental and genetic factors [4]. These traditional risk factors could not directly lead to CAD, and there might be other factors directly leading to atheromatous plaques formation that are related to genetic susceptibility. Renin is mainly secreted by renal juxtaglomerular cells, and it can catalyze the conversion of plasma pro-angiotensin (AGT) into Angiotensin I. Angiotensin I can be further converted into angiotensin

Methods

Results

Conclusion