Abstract
Objective To explore the frequency of Cyclin A1 (CCNA1) and breast vancer dusceptibility gene 1 (BRCA1) gene methylation in patients with non-small cell lung cancer (NSCLC).Methods The methylation specific polymerase chain reaction (MSP) was used to measure the gene methylation status of CCNA1 and BRCA1 in 50 patients with clinically pathologically confirmed NSCLC (experimental group) and 20 patients with benign pulmonary diseases (control group) in order to establish the spectral type of Guangxi NSCLC related genes.Results In 50 cases of NSCLC,CCNA1 and BRCA1 methylation rate was 70.0％ (35/50) and 84.0％ (42/50) respectively.In control group,the DNA of these two genes was demethylated.Conclusion The detection of CCNA1 and BRCA1 gene DNA methylation status is beneficial for the diagnosis of Guangxi NSCLC. Key words: Non-small cell lung cancer; Cyclin A1; Breast vancer dusceptibility gene 1; Methylation
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