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Abstract
The testis transcriptome of mouse strains containing homozygous segments of Mus spretus origin in a Mus musculus background was analyzed.
Highlights
Accumulating evidence points to the mosaic nature of the mouse genome
M. spretus segments in the interspecific recombinant congenic strain (IRCS) are enriched in genes transcriptionally altered compared to B6 In order to explore gene expression in a mosaic mouse genome, we have exploited existing IRCS mice
Homozygous segments of M. spretus origin were introgressed in a M. musculus background
Summary
Accumulating evidence points to the mosaic nature of the mouse genome. little is known about the way the introgressed segments are regulated within the context of the recipient genetic background. Genome Biology 2008, Volume 9, Issue 8, Article R133 L'Hôte et al R133.2 the existence of long segments with extremely high levels of polymorphism (one-third of the genome) This highly polymorphic subgenome is expected to originate partly from multiple subspecies [2], which suggests that the genomes of inbred strains (that is, Mus musculus) are mosaics of chromosome segments derived from other subspecies [1]. These results have been confirmed and extended to other mouse strains derived from the wild [3]
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