Abstract
Diagnosis of Sudden cardiac death (SCD) is challenging for forensic experts. In the current scenario, genetic analysis is rapidly gaining interest in forensic science. Previous studies are not only limited to using protein markers. In this regard, analysis of mRNA is also a key feature. Analysing mRNA offers insight into the diseases and mechanisms leading to death. It can also be used for forensic diagnostic purposes. This review article takes the help of this methodology to discuss about those mRNA species that can aid in the process of sudden cardiac death (SCD) diagnosis. These are mRNA encoding Heat Shock Protein (HSP), mRNA encoding Hemoglobin A1/2 & B, mRNA encoding Pyruvate Dehydrogenase (PDK4), mRNAs encoding Connexin 43 (Cx43) & Zonula occludens-1 (ZO1), mRNA encoding TNNI3, MYL3, TGFB1, MMP9, VEGFA and mRNA expressing Brain Natriuretic Peptide (BNP).Owing to the difficulty of diagnosing SCD, molecular markers are often developed that can aid in the process. Nowadays, mRNA is showing promising usefulness to supplement the process.
 Keywords: Sudden Cardiac Death, forensic, gene expression
Highlights
Sudden cardiac death (SCD) is caused by a plethora of varied cardiac diseases
We have focused on the qualities of mRNA which decide the usefulness of these molecules in diagnosis of SCD during autopsies
Keywords related to the study aim and those included in the search string were: sudden cardiac death, mRNA, forensic diagnosis
Summary
|| Print ISSN: 2589-7837 || Online ISSN: 2581-3935 || International Journal of Medical Science and Diagnosis Research (IJMSDR). Available Online at www.ijmsdr.com NLM (National Library of Medicine ID: 101738824) Volume 4, Issue 9; September: 2020; Page No 06-10. GENE EXPRESSION PATTERN ANALYSIS FOR FORENSIC DIAGNOSIS OF SUDDEN CARDIAC DEATH Saikat Das, Ritwik Ghosh, Dr Soumeek Chowdhuri3 1Junior Doctor (MBBS Intern), Calcutta National Medical College, Kolkata 2Junior Doctor (MBBS Intern), Calcutta National Medical College, Kolkata 3Tutor, Scottish Awardee (IAFM), Department of Forensic and State Medicine, Calcutta National Medical College, Kolkata Calcutta National Medical College, Kolkata, India Conflicts of Interest: Nil Corresponding author: Saikat Das
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