Abstract
In addition to our SV40-transformed hamster cell line (Bloemendal et al. 1980), two otherlenticular cell lines have been established. One was obtained by transformation of hamster lens cells with the carcinogen 3-methylcholanthrene, the other one by transformation of calf lens cells with SV40. The transformed cells revealed alterations in growth pattern and morphology, but only minor changes in gene expression. However, crystallin synthesis ceased in all cases. We hypothesize that elongation of the lens cells in vitro reflects a transition into fibroblast-like cells.
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