Abstract
Sirtuin-1 (Sirt-1) and an endogenous secretory receptor for an advanced glycation end product (esRAGE) are associated with vascular protection. The purpose of this study was to examine the effects of resveratrol (RSV) and caloric restriction (CR) on gene expression of Sirt-1 and esRAGE on serum levels of Sirt1 and esRAGE in healthy and slightly overweight subjects. The study included 48 healthy subjects randomized to 30 days of RSV (500 mg/day) or CR (1000 cal/day). Waist circumference (p = 0.011), TC (p = 0.007), HDL (p = 0.031), non-HDL (p = 0.025), ApoA1 (p = 0.011), and ApoB (p = 0.037) decreased in the CR group. However, TC (p = 0.030), non-HDL (p = 0.010), ApoB (p = 0.034), and HOMA-IR (p = 0.038) increased in the RSV group. RSV and CR increased serum levels of Sirt-1, respectively, from 1.06 ± 0.71 ng/mL to 5.75 ± 2.98 ng/mL (p < 0.0001) and from 1.65 ± 1.81 ng/mL to 5.80 ± 2.23 ng/mL (p < 0.0001). esRAGE serum levels were similar in RSV (p = NS) and CR (p = NS) groups. Significant positive correlation was observed between gene expression changes of Sirt-1 and esRAGE in RSV (r = 0.86; p < 0.0001) and in CR (r = 0.71; p < 0.0001) groups, but not for the changes in serum concentrations. CR promoted increases in the gene expression of esRAGE (post/pre). Future long-term studies are needed to evaluate the impact of these outcomes on vascular health.
Highlights
Sirtuin-1 (Sirt-1) and an endogenous secretory receptor for an advanced glycation end product are associated with vascular protection
For the Caloric restriction (CR) group, we observed that the average caloric intake for the 24 participants was 922.21 ± 27.37 kcal/day
Serum concentration of Sirt1 was increased after both interventions, but showed no difference between study groups
Summary
Sirtuin-1 (Sirt-1) and an endogenous secretory receptor for an advanced glycation end product (esRAGE) are associated with vascular protection. Sirt plays an important role in vascular biology and regulates aspects of age-dependent atherosclerosis. Sirt is found predominantly in the cell nucleus and has a number of modulators such as polyphenolic activators (resveratrol). Animal models confer cardio-protection, reduce neurodegeneration, promote increased fatty acid oxidation and gluconeogenesis in the liver, reduce lipogenesis in the white adipose tissue, and increase insulin secretion in the pancreas and insulin sensitivity in the muscle [1]. Sirt through stimulation of nitric oxide synthase promotes vascular vasodilation, endothelium regeneration, and cardiomyocyte protection under stressful conditions and cellular toxicity to reactive oxygen species [2,3].
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