Abstract

The human dental follicle is an ectomesenchymally derived connective tissue surrounding the tooth germ, containing stem cells of the periodontium has been reported (Morsczeck et al., 2005). Human dental follicle cells (hDFCs) have the capacity to mineralize under in vitro culture using osteogenic induction medium (OIM). Moreover, the transplanted hDFCs with OIM were more capable of mineralization when compared to GM cultured hDFCs under in vivo. However, there is little known that the mechanism or key factor of osteogenic differentiation in hDFCs. The aim of this study was to investigate the key genes in hDFCs during osteogenic differentiation and mineralization using microarray analysis.

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