Abstract
Background: Diabetic foot ulcer (DFU) is a common serious complication of diabetes. Nowadays there is a suggestion that referred to the fact
 the chronicity of DFU is a result of the positive feedback of proinflammatory cytokines production. Objective: This study aimed to display the negative effects of persistent expression of proinflammatory cytokines of (IL-1β and IL-18) under hyperglycemic condition on the DFU microenvironment and clarify the role of growth factor Milk fat globule-epidermal growth factor- 8( MFG-) in the DFU healing process. Approach: Clinical data of a total of 49 type 2 diabetic patients have chronic diabetic foot ulcer grade 2 and 3 (infected DFU n= 29 and non-infected n=21) in addition to the control group (n=25) were participated in the study since June 2021 to April 2022 , venous blood samples were collected for the measurement of the gene expression levels of (IL-1β ; IL-18 and MFG-E8) by Real-Time PCR technique . Results: There was no significant difference in age and sex when compared with the control group at p= 0.798, p =0.514 respectively. High levels of gene expression of (IL-1β ; IL-18 and MFG-E8) were shown in the patients group in comparison to the healthy control.
 Conclusions: Current data confirmed that the inflammatory mediators’ (IL-1β ; IL-18 and MFG-E8) have a strong association with the pathogenesis of DFU healing process.
 
 
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