Abstract
Meeting abstracts An estimated 63,920 cases of kidney cancer will occur in the USA in 2015, and about 13,860 deaths will occur. The incidences of kidney cancer has steadily increased by 2-4% each year. Currently high dose IL (Interleukin)-2, VEGF (vascular endothelial growth factor) inhibitors, and
Highlights
An estimated 63,920 cases of kidney cancer will occur in the USA in 2015, and about 13,860 deaths will occur
We studied both primary and metastatic tumors from FFPE tissue to identify new kinase genes expressed in metastatic tumors compared to primary kidney tumors
There is a cluster of kinase genes over expressed in metastasis, but not in normal and primary tumor
Summary
An estimated 63,920 cases of kidney cancer will occur in the USA in 2015, and about 13,860 deaths will occur. The understanding of biology leading to better treatments will likely require analysis of metastatic tumor tissue, most studies have only analyzed the primary tumor. We studied both primary and metastatic tumors from FFPE tissue to identify new kinase genes expressed in metastatic tumors compared to primary kidney tumors. These data may enable the design of new drugs, since it is relatively easier to design kinase inhibitors
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