Abstract
This contribution is based on the four presentations made at the Special Interest Group (SIG) meeting titled Gene Expression in Fungi held during IMC9 in Edinburgh. This overview is independent from other articles published or that will be published by each speaker. In the SIG meeting, basic principles of in vivo animal models for virulence studies were discussed. Infection associated genes of Candida albicans and fungal adaptation to the host was summarized. Azole susceptibility was evaluated as a combined result of several changes in expression of pertinent genes. Gene transfer in fungi, resulting in fungal evolution and gene adaptation to environmental factors, was reported.
Highlights
Different studies have already described changes in gene expression levels during host-pathogen interactions
Monitoring gene expression by measuring mRNA levels in fungal DNA may identify candidate genes involved in fungal virulence
His work on host-pathogen gene expression in respiratory infection models was presented, and focusses on innate and adaptive host immune responses to Streptococcus and Pseudomonas infections. He provided an overview of his own studies that concentrated on bacterial infection models in animals, and introduced the basic principles of animal studies, which may be similar to those needed in mycological research
Summary
Different studies have already described changes in gene expression levels during host-pathogen interactions. Altered virulence and new phenotypes are a result of the environmental adaptation of fungi during evolutionary processes. Gene expression is the essential mechanism of fungal virulence, and it should be evaluated carefully with regard to future projects to combat fungal disease.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
