Abstract
Gene Expression in Children with Obstructive Sleep Apnea: A Pilot Study
Highlights
Aging is a biological process during lifespan with accumulation of mutations and damages, lowering fitness of at older ages and increasing hazards to survival [1]
We report telomere length results and DNA methylation results, respectively
A significant association was observed between telomere length and all-cause mortality
Summary
Aging is a biological process during lifespan with accumulation of mutations and damages, lowering fitness of at older ages and increasing hazards to survival [1]. Aging is the most important risk factor associated with many diseases, such as cardiovascular disease, cancer, type 2 diabetes, hypertension, and Alzheimer’s disease [2]. It accounts for about two thirds of death worldwide, and an even higher rate of 90% in developed countries. Epigenetics, which refers to changes to the genome that do not involve changes in DNA sequence, have gain popularity in recent research [3]. These epigenetic markers, e.g., telomere length and DNA methylation, can lead to a prediction of biological age or acceleration of aging, and age-related diseases [4]. Telomeres are repetitive noncoding DNA components located at the end of chromosomes to protect from degradation of coding sequences
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