Abstract
Genetic Risk Investigations of the genetic mechanisms underlying neuropsychiatric disease are difficult. Such studies involve a large number of variants of relatively small effect and unknown function. Gamazon et al. computationally examined expressed genes (the transcriptome) in multiple tissues, including the brain, adrenal glands, blood, and colon of 393 individuals. They identified several genetic variants associated with neuropsychiatric disease. The analysis also revealed novel genetic risk factors not previously linked to neuropsychiatric disorders. Some genes show disease-specific expression in nonbrain tissue, such as the adrenal glands and gut, highlighting the need for multiple tissue analyses to pinpoint the cause of these diseases. Nat. Genet. 55 , 933 (2019).
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