Abstract
BackgroundRenal cancer is a common malignant tumor with an increasing incidence rate.MethodsIn this study, based on the gene expression profiles, we analyzed the compositions of tumor-infiltrating immune cells (TIICs) in renal cancer and paracancerous samples using CIBERSORT. The proportions of 22 TIICs subsets in 122 paired renal carcinoma and paracancerous samples, and 224 Wilms tumor (WT) samples varied between intragroup and intergroup.ResultsAfter analyzed the difference of TIICs composition between renal cancer and paired paracancerous samples, we found that M0 macrophages and CD8 T cells were significantly elevated, while naive B cells were significantly decreased in renal cancer samples compared with paracancerous samples. Survival analysis showed that high overall TIICs proportion, the low proportion of resting mast cells and the high proportion of activated memory CD4 T cells were associated with poor prognosis of renal cancer patients. In addition, 3 clusters were identified by hierarchical clustering analysis, and they presented a distinct prognosis. Cluster 1 had superior survival outcomes, while cluster 2 had an inferior survival outcome.ConclusionsOur study indicated that overall TIICs proportion, certain TIICs subset proportion, including resting mast cells and activated memory CD4 T cells, and distinct cluster patterns were associated with the prognosis of renal cancer, which was significant for the clinical surveillance and treatment of renal cancer.
Highlights
Renal cancer is a common malignant tumor with an increasing incidence rate
Performance of CIBERSORT for tumor-infiltrating immune cells (TIICs) evaluation in renal cancer The TIICs composition was analyzed by CIBERSORT
We analyzed the correlation of immune cell proportions in renal cancer samples from The Cancer Genome Atlas (TCGA) and GEO
Summary
Renal cancer is a common malignant tumor with an increasing incidence rate. Renal cancer is a common malignant tumor with an increasing incidence rate over time [1, 2]. Wilms tumor (WT), known as nephroblastoma, is the second most common solid abdominal organ tumor in children and the most frequent primary malignant renal cancer [3]. It accounts for 6% of pediatric cancers, and an estimated 95% of renal cancer is WT among children [4]. It was indicated that tumors might exert an impairment effect on the immune system, and more studies on the associations between TIICs and tumor occurrence and prognosis should be helpful for the application of immunotherapeutic strategies on renal cancer
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