Abstract
The term juvenile rheumatoid arthritis (JRA) is a erm used to describe a heterogeneous group of disorers that share the common characteristic of chronic nflammation and hyperplasia of synovial membranes. he term overlaps, but is not synonymous with, the erms juvenile chronic arthritis (used in the British iterature) and juvenile idiopathic arthritis (a term oming into more common use internationally). For all hree major subtypes of JRA (ie, systemic, polyarticlar, and pauciarticular), the histologic appearance of he inflamed synovium is indistinguishable from that een in adult rheumatoid arthritis, leading many invesigators to conclude that similar pathogenic mechaisms must be involved in these phenotypically disinct diseases. The pathogenesis of JRA is unknown. Current theries of disease pathogenesis have been informed by he following two observations: (1) the presence of D4 T-lymphocytes demonstrating a CD45RO “memory”) phenotype in inflamed synovium; and (2)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Current Problems in Pediatric and Adolescent Health Care
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.