Abstract
The term juvenile rheumatoid arthritis (JRA) is a erm used to describe a heterogeneous group of disorers that share the common characteristic of chronic nflammation and hyperplasia of synovial membranes. he term overlaps, but is not synonymous with, the erms juvenile chronic arthritis (used in the British iterature) and juvenile idiopathic arthritis (a term oming into more common use internationally). For all hree major subtypes of JRA (ie, systemic, polyarticlar, and pauciarticular), the histologic appearance of he inflamed synovium is indistinguishable from that een in adult rheumatoid arthritis, leading many invesigators to conclude that similar pathogenic mechaisms must be involved in these phenotypically disinct diseases. The pathogenesis of JRA is unknown. Current theries of disease pathogenesis have been informed by he following two observations: (1) the presence of D4 T-lymphocytes demonstrating a CD45RO “memory”) phenotype in inflamed synovium; and (2)
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