Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity.

Kexin Sun,Yiqun Wu,Tao Wu,Yonghua Hu,Dafang Chen,Jing Li,Xueying Qin,Pei Gao,Xun Tang,Shaoping Huang,Na Li,Xiao Xiang

doi:10.3390/ijms160714338

Abstract

Soybean is a common food for the Chinese people. We aimed to investigate the risk for brachial ankle pulse wave velocity (baPWV) with inflammatory-related SNPs and soybean. baPWV was measured, and 16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, NOS1, PON1 and CDKN2B were genotyped in 1749 Chinese participants recruited from various communities. ADIPOQ rs12495941 (GT/TT vs. GG: crude OR = 1.27, p = 0.044) and SIRT6 rs107251 (CT/TT vs. CC: crude OR = 0.74, p = 0.009) were associated with abnormal baPWV (baPWV ≥ 1700 cm/s). After adjustment for conventional environmental risk factors, rs12495941 was associated with abnormal baPWV (GT/TT vs. GG: adjusted OR = 1.43, p = 0.011), but the association between rs107251 and abnormal baPWV was not significant (CT/TT vs. CC: adjusted OR = 0.83, p = 0.173). The interaction between rs107251 and soybean intake for different levels of baPWV was statistically significant (p = 0.017). Compared with a high level of soybean intake, a low level of soybean intake can significantly decrease the risk of abnormal baPWV in individuals of rs107251 CT/TT genotypes (≤100 vs. >100 g/week: adjusted OR = 0.542, p = 0.003). In this study, associations between ADIPOQ rs12495941, SIRT6 rs107251 and baPWV, as well as an interaction between SIRT6 rs107251 and soybean intake for different levels of baPWV were found.

Highlights

Pulse wave velocity (PWV) is the speed at which the pulse wave propagates from heart to peripheral arteries [1]
16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, nitric oxide synthase 1 (NOS1), Paraoxonase 1 (PON1) and CDKN2B using a candidate gene approach
The ADIPOQ rs12495941 polymorphism was significantly associated with brachial ankle pulse wave velocity (baPWV) under the dominant model

Summary

Introduction

Pulse wave velocity (PWV) is the speed at which the pulse wave propagates from heart to peripheral arteries [1]. It is widely used in clinical practice as a good surrogate marker of atherosclerosis [2]. Atherosclerosis is known as a chronic inflammatory disease [4,5,6,7]. Genome-wide association studies (GWAS) focused on it have successfully identified numerous disease-associated SNPs located on inflammatory-related genes [8], such as 9p21 [9,10,11]. The links between atherosclerosis and other inflammatory-related genes have attracted much attention.

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