Abstract
Cell-based regeneration of damaged or diseased articular cartilage still faces significant clinical challenge due to inadequate environmental regulation of stem cell proliferation and chondrogenic differentiation. The role of insulin-like growth factor in critical steps of human bone marrow-derived mesenchymal stem cell chondrogenesis has potential in optimizing the therapeutic use of mesenchymal stem cells in cartilage disorders. In addition to the previously described benefits of recombinant adeno-associated viral vector for in vivo gene therapy, demonstrated by Frisch and colleagues, such vector is also a safe and efficient delivery system for the genetic modification of human bone marrow-derived mesenchymal stem cells via ex vivo insulin-like growth factor 1 gene transfer, so that implanted mesenchymal stem cells continuously release a therapeutic level of insulin-like growth factor 1 to achieve sustained mesenchymal stem cell chondrogenesis for cartilage regeneration.
Highlights
No effective treatment for articular cartilage injuries and disorders has been developed to rescue the impaired cartilage or prevent damage progression or both
There is a critical need for the development of a safe and effective delivery system to stably deliver insulin-like growth factor 1 (IGF-1) to achieve a sustained, long-term effect on chondrogenesis of Human mesenchymal stem cell (hMSC)
In a recent issue of Stem Cell Research & Therapy, Frisch and colleagues [1] demonstrate that the ex vivo gene transfer of IGF-1 to stem cells through a recombinant adeno-associated viral vector system, prior to their seeding onto biomaterial or implantation or both, is effective for sustained production of IGF-1
Summary
No effective treatment for articular cartilage injuries and disorders has been developed to rescue the impaired cartilage or prevent damage progression or both. Stem cell-based tissue engineering for cartilage regeneration is a promising alternative pathway in the regeneration of damaged or diseased articular cartilage tissues or both; it needs to be optimized to enhance cell proliferation and chondrogenic
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