GENDER SPECIFICS OF SUBFRACTIONAL PLASMA LIPOPROTEIDS DISTRIBUTION

Abstract

Aim. To find out, whether there is specifics of subfractional distribution of plasma lipoproteides in men and women depending on coronary atherosclerosis. Material and methods. Totally 310 patients included (203 males, 107 females), underwent coronary arteriography; lesion of artery was assessed with Gensini Score (GS). Subfractional spectrum of plasma lipoproteides was studied via electrophoresis in 3% polyacrylamid gel with Lipoprint system (Quantimetrix Lipoprint System, USA). Results. In the group without lesion (GS =0) gender differences of lipids, apolipoproteides and glucose utilization parameters were absent. Among coronary atherosclerosis patients (GS >0) males had lower concentrations of low and high density cholesterol (LDL, HDL), as Apo A1 and Apo B. Males with GS =0, as with GS >0 differed from females by lower lipoproteides of intermediate density (LID) — LID B and LID A, and higher part of LDL 2 and small dense particles LDL 3, but mean size of LDL particles was smaller. There were no differences in HDL subfractions distribution among men and women, but in men only if coronary atherosclerosis, there were lower cholesterol concentrations found in all HDL subfractions. Conclusion. Gender differences are revealed in subfractional spectrum of LID and LDL: in men regardless coronary atherosclerosis with the same and even lower level of LDL cholesterol there was accumulation of more atherogenic small dense LDL particles. Gender differences in the part of HDL subfractions were not found, but in men concentration of cholesterol in each of subfractions, with coronary lesion, was lower than in women.