Abstract
Hepatic lipase (LIPC) is a key rate-limiting enzyme in lipoprotein catabolism pathways involved in the development of obesity. The C-514T polymorphism in the promoter region is associated with decreased LIPC activity. We performed a case-controlled study (850 obese children and 2119 controls) and evaluated the association between LIPC C-514T polymorphism, obesity and plasma lipid profile in Chinese children and adolescents. Additionally, we conducted a meta-analysis of all results from published studies as well as our own data. A significant association between the polymorphism and obesity is observed in boys (P = 0.042), but not in girls. And we observed a significant relationship of the polymorphism with total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) independent of obesity in boys. The T allele carriers have higher levels of low density lipoprotein cholesterol (LDL-C) in obese boys, and triglyceride (TG), TC and LDL-C in non-obese girls (all P < 0.05). In the meta-analysis, under dominant model the T allele increased body mass index (BMI) level in boys, while it decreased BMI in girls, and increased the levels of TC both in the overall and subgroups, TG and HDL-C in the overall and boys, and LDL-C in the overall (all P < 0.05). Our results suggest that the T allele might carry an increased risk of obesity in Chinese boys. The meta-analysis suggests that T allele acts as a risk allele for higher BMI levels in male childhood, while it is a protective allele in female childhood. And the polymorphism is associated with the levels of plasma lipids, which may be modulated by obesity and gender.
Highlights
The hepatic lipase gene (LIPC) is a member of the lipase gene family, in which protein sequence homology with other lipases is 30–75% [1]
Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine
We explored the associations between the LIPC C-514T polymorphism, obesity and plasma lipid profiling in a representative sample of Chinese children and adolescents
Summary
The hepatic lipase gene (LIPC) is a member of the lipase gene family, in which protein sequence homology with other lipases is 30–75% [1]. LIPC has been cloned from two human liver cDNA libraries by cross-hybridization with the determined rat cDNA clone [2]. It is a secretory glycoprotein enzyme synthesized predominantly by the liver, and distributed on the surfaces of hepatocytes and sinusoidal endothelium [3]. Since it plays an important role in lipoprotein catabolism pathways [3], LIPC has been implicated in the risk of coronary artery disease, where its effect is dependent on the underlying lipoprotein phenotype or disorder [4]. LIPC was identified as an obesity candidate gene in a mouse model, LIPC deficient mouse can be protected against diet-in-
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