Abstract
Background. Insulin induced gene 2 (INSIG2) encodes a protein that has a biological effect on regulation of adipocyte metabolism and body weight. This study aimed to investigate the association of INSIG2 gene -102G>A polymorphism with obesity related phenotypes in Chinese children and test gender-specific effects. Methods. The 2,030 independent individuals aged from 7 to 18 years, including 705 obese cases and 1,325 nonobese controls, were recruited from local schools. We measured the obesity-related phenotypes and detected the serum lipids. We genotype -102G>A polymorphism by using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Results. In all individuals, we found that the GG/GA genotype of INSIG2 -102G>A polymorphism was associated with risk of severe obesity (OR = 1.62, 95% CI: 1.11–2.36, and P = 0.012) under the dominant model. The association with severe obesity existed only in boys (OR = 1.91, 95% CI: 1.15–3.17, P = 0.012). The GG/GA genotype of -102G>A polymorphism was also associated with higher waist circumference (β = 2.61 cm, P = 0.031) in boys. No similar association was found in girls. The polymorphism was not associated with other obesity-related phenotypes, neither in all individuals nor in gender-specific population. Conclusions. This study identified a gender-specific effect of INSIG2 -102G>A polymorphism on risk of severe obesity and waist circumference in Chinese boys.
Highlights
Obesity has been associated with many common medical conditions, such as type 2 diabetes, hypertension, cardiovascular disease, stroke, and physical disabilities [1]
The levels of Body mass index (BMI), waist circumference, hip circumference, total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), and skinfold thickness were higher in obese group (P ≤ 0.001), while the high-density lipoprotein cholesterol (HDL-C) level was lower in obese group, compared with controls (P < 0.001)
The results were similar in nonobese participants (P > 0.05, data not shown). This is the first study to investigate the association between -102G>A polymorphism and obesityrelated phenotypes in Chinese children
Summary
Obesity has been associated with many common medical conditions, such as type 2 diabetes, hypertension, cardiovascular disease, stroke, and physical disabilities [1]. In the previous study of our research group, the frequency of rs7566605 CC genotype frequency in severe obese group (BMI ≥ 97th percentile) was higher than that of normal-weight group [12]. These evidences showed that the upstream region of INSIG2 gene might be involved in weight regulation [11, 12]. This study aimed to investigate the association of INSIG2 gene -102G>A polymorphism with obesity related phenotypes in Chinese children and test gender-specific effects. This study identified a gender-specific effect of INSIG2 -102G>A polymorphism on risk of severe obesity and waist circumference in Chinese boys
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