Abstract
The association of parathyroid hormone (PTH) and vitamin D with Metabolic syndrome (MetS) was evaluated using representative data from the Korean population. Data from 7004 subjects aged 50 or older with preserved renal function (excluding chronic kidney disease stage 3b to 5) who were included in the Korean National Health and Nutrition Examination Survey between 2008 and 2010 were analysed. Higher PTH levels (pg/ml) were observed in subjects with MetS than in those without MetS among both genders (60.1 (58.6–61.6) vs. 62.4 (60.7–64.2) in males p = 0.018, 60.7 (59.4–62.1) vs. 63.9 (62.4–65.6) in females, p < 0.001). For females, PTH levels were significantly higher in subjects with MetS than in those without MetS after adjustment for possible covariates. Lower 25(OH)D levels were significantly associated with MetS only in male subjects (p = 0.004). As the number of MetS components increased, a significant rise in PTH levels (p for trend 0.005 in males and 0.024 in females) and a decrease in 25(OH)D levels (p for trend < 0.001 in males and 0.053 in females) were observed. In conclusion, among subjects with preserved renal function, PTH levels were possibly associated with MetS in females, whereas vitamin D levels exhibited a possible link to MetS in males.
Highlights
Parathyroid hormone (PTH) and vitamin D are the primary regulators of calcium homeostasis
A significant association of parathyroid hormone (PTH) and vitamin D with Metabolic syndrome (MetS) was found in an analysis of representative nationwide data of the middle-aged Korean population with preserved renal function
Significant increases in PTH levels in both genders and a decrease in vitamin D levels in males were observed based on the number of MetS components present
Summary
Parathyroid hormone (PTH) and vitamin D are the primary regulators of calcium homeostasis. Several studies have evaluated the relationship between PTH/vitamin D and MetS in large population-based datasets[4,6,7,8,9,10,11,12,13,14,15], but the results were inconsistent. Recent results from the Korean National Health and Nutrition Examination Survey (KNHANES) had no exclusion criteria for subjects with renal impairment, and the status of renal function based on the GFR was not considered in the evaluation of the relationship between PTH/vitamin D and MetS15. The aim of this study is to elucidate the associations of PTH and vitamin D with MetS in subjects with normal kidney function using representative datasets of the Korean population
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