Abstract
Elevated levels of serum uric acid (SUA) were considered to be risk factors for cardiovascular disease, it has been found to be associated with increased arteriosclerosis. The aim of this study was to explore the gender specific relationship between SUA and fundus arteriosclerosis in a healthy population. In a retrospective cross-sectional study, 23474 individuals without diabetes and hypertension were included in the present study. SUA levels were cut to four groups as Q1 to Q4, according to the quartiles. The odds ratio and 95% confidence interval of different SUA levels were estimated by a binomial logistic regression model. A restrictive cubic spline method was used to estimate the dose-response relationship between SUA and fundus arteriosclerosis. Subgroup analysis was performed to find the gender-specific association between SUA and incident fundus arteriosclerosis. In males, after adjusting for confounding factors, the highest SUA level was significantly associated with the risk of incident fundus arteriosclerosis. The OR with 95%CI for Q4 was 1.44(1.18, 1.76), Q1 as a reference. Specially, for females, SUA level was not associated with the incidence of fundus arteriosclerosis. In conclusion, elevated levels of SUA were associated with the incidence of fundus arteriosclerosis in males, but not in females.
Highlights
Estimated glomerular filtration rate; TG: triglycerides; TC: total cholesterol; low-density lipoprotein (LDL): low density lipoprotein; high-density lipoprotein (HDL): high density lipoprotein
We could find that the incidence of fundus arteriosclerosis gradually increases with the increase of Serum uric acid (SUA) levels (p for trend
The results of this study showed that 9.3% of people without diabetes and hypertension showed signs of fundus arteriosclerosis
Summary
Estimated glomerular filtration rate; TG: triglycerides; TC: total cholesterol; LDL: low density lipoprotein; HDL: high density lipoprotein. Recent studies have shown that elevated SUA levels may be associated with a higher risk of increased arteriosclerosis in normotensive subjects[22], and SUA could be used as a predictor of atherosclerosis[27]. Animal experiment has shown that the administration of allopurinol and benzbromarone prevented the development of atherosclerosis in apoE (−/−) mice fed a uric acid-enriched diet[25]. Given these discordant results, the association between elevated uric acid and arteriosclerosis remains controversial. The association between elevated uric acid and arteriosclerosis remains controversial This association has been relatively underexplored in healthy population. We analyzed the relationship between SUA and funds arteriosclerosis in healthy examination population by a retrospective cross-sectional study, and explored whether there was a dose response relationship between them
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