Abstract
BackgroundHeterogeneity should be carefully addressed to facilitate establishment of effective population-level blood lipid management. The primary aim of the study was to investigate gender heterogeneity in prevalence of dyslipidemia, including trends with age and associated factors in middle age rural Chinese.MethodsThis is a cross-sectional study based on a baseline investigation of a population-based randomized controlled trial in rural China, involving 26,378 permanent residents of age 45–69. The age-specific prevalence of dyslipidemia was estimated for men and women, and the trends of prevalence with age were compared. Logistic regression was used to explore the factors associated with prevalent risk of dyslipidemia.ResultsThe overall prevalence of dyslipidemia was significantly higher in females than in males for borderline high and above (BHA) total cholesterol (TC ≥ 200 mg/dL), BHA triglycerides (TG ≥ 150 mg/dL) and BHA low-density lipoprotein cholesterol (LDL-C ≥ 130 mg/dL), but was lower for low high-density lipoprotein cholesterol (HDL-C < 40 mg/dL) in females than the corresponding prevalence in males. The prevalence of borderline high and above TC, TG and LDL-C all rose with age in females, but was stable or even decreased with age in males. In contrast, graphic representation of the prevalence of low HDL-C showed no striking age related trend in both genders. Risk of dyslipidemia was associated predominantly with obesity in males, but was more predominantly associated with hypertension in females.ConclusionHeterogeneity was found in comparing the prevalence of dyslipidemia in men and women, and gender heterogeneity was found in its trend with age and associated factors in middle aged rural Chinese. The effectiveness of population-level blood lipid management and CVD primary prevention programs in China is expected to be improved if gender heterogeneity is considered.
Highlights
Blood lipids are fatty substances free in the blood or bound to other molecules
In evaluation of the four lipid indicators, females had significantly higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) compared with male participants (P < 0.001)
Results from this study showed that prevalence of HDL-C abnormality had a completely different agerelated trend as compared to that of TC, TG and LDLC
Summary
Blood lipids are fatty substances free in the blood or bound to other molecules. Lipids play a significant role in energy storage, cell membrane structure, cytokine synthesis, signal transmission and overall basal metabolism [1]. Within numerous different lipids and lipoproteins, triglycerides (TG), total cholesterol (TC), and the two major components of TC namely low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), are the most commonly used indicators and control targets in clinical settings and population-level intervention projects. Basic data regarding prevalence and factors associated with these lipid indicators provides a foundation for establishing strategies for blood lipid management, and this is a key step in the primary prevention of CVD [8]. Heterogeneity should be carefully addressed to facilitate establishment of effective population-level blood lipid management. The primary aim of the study was to investigate gender heterogeneity in prevalence of dyslipidemia, including trends with age and associated factors in middle age rural Chinese
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