GENDER FEATURES OF THE VEGETATIVE STATUS AND RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM ACTIVITY IN HEALTHY PERSONS AND PATIENTS WITH METABOLIC SYNDROME: PP.34.390

Abstract

Objective: To investigate gender differences of heart rate variability (HRV) time domain and its associations with the components of renin-angiotensin-aldosterone system (RAAS) in healthy persons and patients with metabolic syndrome (MS). Methods: there were investigated 84 patients (52 perimenopausal women and 32 men) with MS (mean age 54.3 ± 5.4 years) and 15 healthy volunteers (10 women and 5 men) with comparable characteristics. All participants underwent 24-hours ECG-monitoring for the estimation of the HRV. Plasma renin activity and serum aldosterone levels were detected by immune-enzyme assay. The results were processed with SPSS-11.0 software. Results: RMSSD was significantly higher in healthy females in contrast to healthy men 53.9 ± 28.2 è 30.8 ± 7.2 (p < 0.05), accordingly. Women with MS revealed lower HRV time domain unlike healthy females: SDNN 134.5 ± 42.0 and 160.3 ± 21.1, SDANN 128.0 ± 30.0 and 143.9 ± 18.9, SDNNi 29.7 ± 13.0 and 42.4 ± 13.9, RMSSD 39.0 ± 24.5 and 50.6 ± 28.2 (ð < 0.05), respectively. HRV parameters in the group of healthy males and male patients with MS did not differ. Correlation analysis in female hypertensives disclosed association of SDANN with both plasma renin activity (r = 0.91, p = 0.01) and serum aldosterone level (r = 0.83, p = 0.002), and RMSSD with plasma renin activity (r = -0.52, p = 0.05). Conclusion: healthy females have been demonstrated more vagal activity in contrast to healthy males. In perimenopausal females with MS there have been revealed depression of all HRV parameters, which is typical for sympathetic activation, and their relations to the components of RAAS.