Gender Features of the Prevalence, Development and Progression of Left Ventricle Hypertrophy in Chronic Kidney Disease

Abstract

Aim of the Study: To study the features of the prevalence of left ventricular hypertrophy in chronic kidney disease, taking into account gender differences. Materials and Methods: This were an instant study. We examined 945 patients (360 female and 585 male) with chronic kidney disease (CKD) from the 1st to the 5th stage of the disease. The average age of the patients was 39.0±13.0 years. Glomerular filtration rate (GFR) was calculated using the CKD-EPI formula. Results: In patients with female CKD, a significant decrease in hemoglobin, erythrocyte count, and eGFR was detected compared with males, while the incidence of hyperuricemia was significantly higher. Daily proteinuria was significantly higher in men compared with women. The prevalence of LVH was significantly higher in females compared with men (49.4% versus 35.7%; p<0.05). In women and men, the eccentric type prevailed in the structure of LVH. The number of patients with an eccentric type of LVH was significantly higher in the subgroup of females (p<0.05), and with concentric remodeling of the LV were significantly higher in males (p<0.05). Conclusion: The prevalence of LVH among the examined individuals with CKD was 40.9%. Among women, the most common type of LVH was the eccentric type of remodeling (79.2%), and among men, the concentric type of LVH was 39.7% of cases.