Gender Disparities among Japanese Renal Cell Carcinoma Patients Residing In the United States

Abstract

Abstract Background Numerous cancers including renal cell carcinoma (RCC) have been shown to have a significant survival disparity among genders with better survival in females. In this study, we aim to utilize a large cohort of Japanese patients to evaluate gender disparities in RCC survival thoroughly. Methods Data of Japanese patients with RCC diagnosed between 1973 and 2015 in the US was obtained using the American SEER database. We studied the overall and cancer-specific survival of Japanese patients according to different demographic and tumor-related factors, using Kaplan-Meier test and Cox models. Results We reviewed 1,142 patients of Japanese origins who median overall survival that was 92 months (95% CI, 80.592-103.408), and a median RCC-specific survival that was 196 months (95% CI, 148.187-243.813). Females showed a significantly better overall survival (p-value Conclusion An apparent better survival was observed in Japanese female RCC patients; however, once adjusted for different baseline characteristics, gender no longer played a significant role in patient survival. Larger studies with more patients are needed to confirm these results in Japanese patients.