Abstract
Aims. To investigate the trend of metabolic syndrome and its components in Tehran children and adolescents during a median followup of 6.6 years. Methods. Data from 1999–2001 (phase I), 2002–2005 (phase II), and 2006–2008 (phase III) of the Tehran, Lipid and Glucose Study were analyzed (n = 5439; age 6–18 years) for the trend of metabolic syndrome (MetS) and its components. General estimation equation (GEE) models were used to analyze this correlated data. Results. The crude prevalence of MetS for boys at baseline was 13.2%, which increased to 16.4% in the third phase. In girls, the prevalence of Mets decreased from 11.8% at baseline to 6% during followup. The odd ratios (OR) of obesity over the whole study period were raised in both sexes. The OR of abdominal obesity increased significantly in boys, but no change was observed in girls. No significant OR was observed in boys, while OR for MetS was shown to have a decreasing trend in girls during the followup. In the three time points, the ORs of MetS decreased significantly in girls but no significant difference was observed in boys. Conclusion. Inspite of increasing trend for obesity in both sexes, the trend of MetS decreased in girls and was relatively stable in boys, in Tehranian children, and adolescents.
Highlights
The metabolic syndrome (MetS) is defined as a clustering of metabolic risk factors including central obesity, hyperglycemia, dyslipidemia, and hypertension [1]
Obesity and metabolic risk factors among children and adolescents have been much focused on several studies showing that increasing obesity and MetS in this population is associated with a number of adverse consequences in adulthood including type 2 diabetes mellitus and coronary heart disease, most likely due to overproduction of inflammatory mediators and insulin resistance [2,3,4]
Given the above-mentioned limitations in this study, we aimed to examine the trend of MetS and its components from childhood to adolescence, due a mean of 6.6 years of followup for the first time in Middle East region using general estimation equation (GEE) analysis
Summary
The metabolic syndrome (MetS) is defined as a clustering of metabolic risk factors including central obesity, hyperglycemia, dyslipidemia, and hypertension [1]. Obesity and metabolic risk factors among children and adolescents have been much focused on several studies showing that increasing obesity and MetS in this population is associated with a number of adverse consequences in adulthood including type 2 diabetes mellitus and coronary heart disease, most likely due to overproduction of inflammatory mediators and insulin resistance [2,3,4]. Previous studies demonstrated higher triglyceride and lower HDL-C levels in Iranian adolescents compared to their American counterparts [8, 9]. This increased prevalence would necessitate the need for identifying the time trend of Mets and its components in our population. The prevalence and associated risk factors of MetS have been widely studied in recent decades [10,11,12], much less is known in regard to changes in risk factor status over a longer period of time during childhood and adolescence, in developing countries like Iran
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
