Abstract

 To evaluate and compare serum Leptin hormone level between Iraqi male & female and the relation between this hormone & BMI in these two groups.
 A total of 44 normal male & female subjects were included in this study
 {Group 1 : 22 female } , { Group 2 : 22 male}.
 Serum Leptin hormone ,BMI &fasting blood glucose were measured for both groups.
 Serum Leptin level in group 1 was (8.82 + 2.9 μg/L) where as in group 2 it was (4.65 + 3.2 μg/L) . These changes were statistically significant. Fasting blood glucose levels were technically within the normal value (116.43 + 3.4mg /dl) for group 1 & (118.52 + 2.9 mg /dl) for group 2 . BMI levels were comparable in both groups during the study, with slight elevation in group 1 [ 24 + 1.73 kg /m2 for group 1 & 23 + 1.98 kg /m2for group 2 ] which within the acceptable limit as far as safety concern.
 Leptin, an adipocyte-derived hormone known to play an important role in body-weight regulation, the result of this study shows that Leptin is presented differentially in Iraqi men and women ; in which it is significantly higher in women than in men serum . These observations are potentially important for the understanding of differences between men and women in regulation of food intake, weight gain, and body fat distribution.The relation between Leptin & the BMI in male and female in this study may open another approach for this hormone to be involved in –fertility & in pubertal development.
Highlights
Leptin is a recently discovered hormone[1] that is mainly synthesized by adipose cells and secreted into the bloodstream in amounts relative to the quantity of body fat
Plasma leptin levels in humans are strongly correlated with body mass index (BMI) and total fat mass (Figure 1) and are elevated in obese subjects.[2]
Leptin levels are very high in obese people, which suggests the existence of a leptin – resistance state, analogous to insulin-resistance in type 2 diabetes,[4] the exact mechanisms for this resistance are not clear yet
Summary
Leptin is a recently discovered hormone[1] that is mainly synthesized by adipose cells and secreted into the bloodstream in amounts relative to the quantity of body fat. Plasma leptin levels in humans are strongly correlated with body mass index (BMI) and total fat mass (Figure 1) and are elevated in obese subjects.[2]. Leptin is thought to have an "adipostat" function;that is, it acts as a signal informing the brain about the amount of fat stored in the body, through which the brain can regulate energy intake and energy expenditure in order to keep body weight constant (Figure 1).[3,4] , when leptin levels are low, appetite will be stimulated with limited use of energy, and w hen leptin levels are high, appetite is reduced and energy use is stimulated. Leptin levels are very high in obese people , which suggests the existence of a leptin – resistance state , analogous to insulin-resistance in type 2 diabetes,[4] the exact mechanisms for this resistance are not clear yet
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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