Abstract
Background/Objectives: Peripheral arterial disease is a frequent and severe disease with high cardiovascular morbidity and mortality. However, female patients appear to be undertreated. Objectives: The primary goal was to compare the prescription of optimal medical treatment (OMT) of peripheral arterial disease between women and men in primary health care. Material and methods: An observational retrospective study was based on the data collected from general practitioners (GP) office in Brittany. Results: The study included 100 patients, aged 71 ± 10 years old, with 24% of women. Compared to men, women received the OMT less frequently (29.2% vs. 53.9%, p = 0.038), especially after 75 years old. Antiplatelet therapy was largely prescribed (100%), statins less frequently (70.8% women vs. 85.5% men), and prescription of renin-angiotensin-aldosterone system inhibitors was still not optimal in the two genders (41.7% women vs. 61.9% men). Active smoking is important for both women and men (33% and 30% respectively). Conclusion: Optimal medical treatment of peripheral artery disease is insufficiently prescribed, especially in women in this region of France.
Highlights
Lower extremity peripheral arterial disease (PAD) is a frequent and increasing pathology, estimated at 235 million people affected worldwide and associated with substantial morbidity and mortality [1]
Lifestyle change and optimal medical treatment are the core of the treatment [2,3,4]
The present study examined the effect of gender on treatment medical management in patients with PAD in primary health care
Summary
Lower extremity peripheral arterial disease (PAD) is a frequent and increasing pathology, estimated at 235 million people affected worldwide and associated with substantial morbidity and mortality [1]. Lifestyle change and optimal medical treatment are the core of the treatment [2,3,4]. ARBs) is the Optimal Medical Treatment (OMT) for PAD [5]. PAD in women is less frequent than in age-matched men; women are more likely to have atypical symptoms and greater walking impairment with progressive functional decline [6,7,8,9,10]. Research into gender differences in the prescription of medical and lifestyle therapies for PAD is lacking but women are treated less intensively to achieve cardiovascular risk factor targets [11] and appear to be treated less favorably for PAD than men at discharge from a tertiary-care teaching hospital [12]. Scientific statements have increasingly promoted the need for increased awareness and further research into gender-specific concerns in PAD. Women have been consistently underrepresented in clinical trials [6] and, conclusions are hard to draw from case reports
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