Gender differences in risk of myocardial infarction and stroke in population with sleep disorders in Russia / Siberia: population-based study MONICA-psychosocial

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. Objectives To determine the gender differences in the effect of sleep disorders on risk of myocardial infarction (MI) and stroke in population 25-64 years over 16 years of follow-up. Methods Under the third screening of WHO program MONICA -Psychosocial a random representative sample of both gender aged 25- 64 years in Novosibirsk was examined in 1994 (n = 1346, male 48.8%, mean age 44,9 ± 0,4 years). The sleep assessment was performed using the Jenkins Sleep Questionnaire. There were 15 cases of new-onset MI in women and 30 in men, new-onset stroke 35 cases in women and 22 in men from 1994 to 2010. Results In an open population aged 25-64 years 48.6% of men and 65.9% of women had sleep disorders (p< 0.001). Univariate analysis showed 2.4-fold risk of MI in those males with SD over 16-year of follow-up (95%CI 1.1-5.3; p< 0.05) but not for women. MI risk was higher in those men who were never married, divorced or widowed (p for all <0.01) compared to married ones. Risk of stroke was higher in men HR = 3 (95%CI 1.2-7.6;p < 0.05) than in women HR = 1.9 (95%CI 1.03-3.7; p < 0.05). Multivariate analysis revealed 2.8-fold risk of stroke (95%CI 1.1-7.1; p < 0.05) in men and HR = 2.7 in women (95%CI 1.4-5.42;p < 0.01) with SD. Stroke risk was higher in men with lower educational level and in women with college degree in those with SD. Conclusions Sleep disorders is a risk factor of MI in men only and stroke for both gender and negative social gradient increases cardiovascular risk.