Gender differences in relative survival among patients with primary peritoneal carcinoma.

Abstract

e13092 Background: Primary peritoneal cancer(PPC) is a very rare aggressive cancer and is usually diagnosed late due to which it is generally portrays a poor prognosis. There are very few retrospective studies with limited knowledge about PPC. NCCN treatment guidelines for PPC is the same as that of ovarian cancer. Methods: We used 18 registries from Surveillance, Epidemiology, and End Results database to identify 6570 patients with Primary peritoneal carcinoma from 2000 to 2012 with follow up period upto 2015. Actuarial method was used to calculate 1 and 3 year Relative Survival (RS). Covariates included age, sex, race and grade. Results: PPC occurs more commonly in women with about 93% of the cases documented in women and about 88% of those documented in white women as per this database. The 1-year and 3-year RS for white women was 77.7% and 46% versus 69.6% and 54.1% for white males respectively. Males with grade I and grade II cancers had a better 3-year RS of 88.1% and 64.6%, in comparison with females with 77.3% and 55% respectively. Females with grade III and Grade IV cancers had a better 3 -year survival of 47.9% and 49% versus males who has a RS of only 35.3% and 39%. RS was significantly better in patients < 60 years with 3-year RS rate of 60.9% versus 36.4% for patients > 70 years. 3-year RS rates at during 2000-04, 2005-09 and 2010-14 were similar with 43.8%, 48.7% and 48.5% respectively. Conclusions: PPC is treated in a similar manner to epithelial ovarian carcinoma given some of its similarities in biological and pathological behavior. The cause of primary peritoneal cancer in unknown and there are only few studies done due to paucity of cases. Over the years survival seems to have not changed significantly and we need more clinical trials to identify the best course of treatment. [Table: see text][Table: see text][Table: see text][Table: see text]