Abstract
Differences in the immune and inflammatory response were revealed in the lungs of male and female Wistar rats on day 1 after administration of LPS in a dose inducing the development of acute bacterial endotoxemia. Females showed more pronounced morphofunctional signs of immune system activation than males: this was characterized by more severe accidental involution of the thymus, devastation of the splenic white pulp, and enhanced production of IL-4, IL-12, and TNF-α by splenocytes. In males, production of the above cytokines decreased and inflammation in the lungs was more pronounced at these terms.
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