Gender differences in patterns of cartilage loss: Data from the Osteoarthritis Initiative

Abstract

OBJECTIVEUnderstanding gender-specific differences in patterns of cartilage loss can improve our knowledge of the pathogenesis of knee osteoarthritis (KOA) development and progression and may inform clinical trials of treatments for KOA. The goal of our observational study was to examine gender differences in patterns of cartilage loss in the central weight-bearing regions of the femur. METHODSWe measured cartilage volume change in the indexed knee of 700 subjects with Kellgren-Lawrence (KL) 1, 2, or 3 from the OAI for four follow-up periods (BL to 24mo, BL to 48mo, BL to 72mo, and BL to 96mo) using the local area cartilage segmentation (LACS) method. Briefly, the LACS method uses robust coordinate systems fixed to anatomical landmarks to measure patterns of change in cartilage volume in sub-regions using responsiveness heat maps. RESULTSWe observed a statistically significant gender difference in cartilage change in the medial femur (MF), lateral femur (LF), and medial tibia (MT). The heat maps, showed loss was primarily in the posterior central weight-bearing portion of the LF and more general in the LT and MF. Similar patterns were observed for each of the four follow-up periods. CONCLUSIONSThe LACS method was capable of illustrating gender-specific differences in patterns of cartilage loss that may offer insight into the variation of gender differences in the natural history of KOA and may be useful in evaluating the benefit of interventions for KOA.