Gender differences in myocardial salvage and clinical outcome in patients with acute reperfused ST-elevation myocardial infarction

Ingo Eitel,Matthias Gutberlet,Gerhard Schuler,Holger Thiele,Georg Fuernau,Steffen Desch

doi:10.1186/1532-429x-13-s1-o86

Abstract

There is conflicting evidence regarding gender-based differences in outcomes in patients after myocardial infarction. Recently, a study demonstrated greater myocardial salvage assessed with SPECT imaging in women than in men. However, SPECT imaging has several limitations including its low spatial resolution particularly of subendocardial infarcts and as a result cardiac magnetic resonance imaging (CMR) has emerged as the reference method to assess myocardial salvage.

Highlights

There is conflicting evidence regarding gender-based differences in outcomes in patients after myocardial infarction
The aim of this study was to investigate whether there are gender-associated differences in the amount of myocardial salvage assessed by cardiac magnetic resonance imaging (CMR) and clinical outcome in ST-elevation myocardial infarction (STEMI) patients reperfused by primary percutaneous coronary intervention (PCI)
The secondary end point was the occurrence of major adverse cardiovascular events (MACE) defined as death, reinfarction and occurrence of new congestive heart failure within 6 months after the index event

Summary

Introduction

There is conflicting evidence regarding gender-based differences in outcomes in patients after myocardial infarction. A study demonstrated greater myocardial salvage assessed with SPECT imaging in women than in men. SPECT imaging has several limitations including its low spatial resolution of subendocardial infarcts and as a result cardiac magnetic resonance imaging (CMR) has emerged as the reference method to assess myocardial salvage. Purpose The aim of this study was to investigate whether there are gender-associated differences in the amount of myocardial salvage assessed by CMR and clinical outcome in ST-elevation myocardial infarction (STEMI) patients reperfused by primary percutaneous coronary intervention (PCI)

Objectives

Results

Conclusion